Per Wikipedia, Kounis syndrome, also referred to as allergic angina, is “a group of symptoms that manifests as unstable vasospastic, nonvasospastic angina, or acute myocardial infarction and is triggered by the release of inflammatory mediators following an allergic insult.”
Lisa Klimas adds this: “The phenomenon we now called Kounis Syndrome has previously been called by names like morphologic cardiac reactions, acute carditis and lesions with basic characteristics of rheumatic carditis. It is sometimes still referred to as allergic angina or allergic myocardial infarction/heart attack depending upon the presentation. Allergic angina, which affected patients as microvascular angina, was first noted to progress to allergic heart attack in 1991.”
From my perspective as someone just learning about mast cell activation disease, it’s interesting to see that this was known in 1991, but mast cell activation diseases weren’t really recognized until 2007 to 2010.
