MCAS/MCAD: What an activated mast cell looks like alvin June 13, 2019 - 3:38pm

At some point somebody was like, “Let’s get a mast cell — a type of white blood cell — from a bone marrow biopsy, magnify it 1,000 times, piss it off, and see what happens.”

The result? Ka-boom! It looks like a little firework went off when it released its histamine, tryptase, serotonin, superoxide, heparin, thromboxane, PGD2, PAF, and other granules.

That’s pretty much what it feels like, lol. I used to tell doctors that it felt like I had been drugged, and indeed, I was.

(Image from this research paper.)

Tryptase blood test for mastocytosis

A doctor at the University of Colorado had my blood drawn two weeks ago to test the tryptase level(s) to see if I have an illness called “Mastocytosis.” This page at has a good description of the symptoms of mastocytosis (as shown in this image), along with the reasons why doctors test the tryptase levels as a way to evaluate mastocytosis, along with other things like anaphylaxis (anaphylactic shock).