As a brief personal note, I just remembered that back during 2014-2017 when I went unconscious seven times — a process known as syncope, and pronounced sync-oh-pee — I would later find out that the reason I went unconscious is because I didn’t feel the initial symptoms of MCAS. Those initial symptoms were suppressed because I was taking a statin.
So while I was taking a statin I would feel sick, like I’d been poisoned, and then go unconscious in a process that took 2-15 minutes. But on September 1, 2016, I stopped taking the statin because of some things that happened in the previous days. To my surprise, after I stopped taking the statin I would feel bad from the MCAS much earlier in the process, and then I’d also get hives, rashes, and other symptoms hours before entering pre-syncope. This gave me an opportunity to take more medicine to avoid the actual syncope event.
So, my personal experience is that taking a statin suppressed the initial mast cell disease symptoms, and that led me to go directly to syncope events without first having hives, rashes, etc.